Immunoglobulin G, A and M response to influenza vaccination in different age groups: effects of priming and boosting
Identifieur interne : 002370 ( Main/Exploration ); précédent : 002369; suivant : 002371Immunoglobulin G, A and M response to influenza vaccination in different age groups: effects of priming and boosting
Auteurs : Walter E. P. Beyer [Pays-Bas] ; Jos T. M. Van Der Logt [Pays-Bas] ; Ruud Van Beek [Pays-Bas] ; Nic Masurel [Pays-Bas]Source :
- Journal of Hygiene [ 0022-1724 ] ; 1986-06.
Abstract
Fifty volunteers, treated with an inactivated trivalent influenza vaccine containing A/Bangkok/1/79 (H3N2), A/Brazil/11/78 (H1N1) and B/Singapore/222/79 virus, were subdivided according to the estimated first exposure to influenza in their lifetime (priming) and the presence of antibodies against the vaccine components in the pre-vaccination sera. The isotypic antibody response (IgG, IgA, IgM) was determined by means of an antibody capture haemadsorption immunosorbent technique. For all three vaccine components, previously seropositive subjects produced antibodies of the IgG- and IgA-class more frequently than previously seronegative persons. Subjects primed to one of the influenza A subtypes showed more IgG and IgA responses in comparison with those unprimed (prime-effect). In contrast, IgM antibodies occurred in only 19 and 11% of primed, but in 59 and 54% of unprimed subjects, for A (H3N2) and A (HlNl), respectively. The incidence of IgM titre rises was not influenced by the prevaccination state. However, the mean magnitude of anti-A(H1N1)-IgM titre rises was greater in those previously seronegative. The concepts of primary and reinfection and of ‘original antigenic sin’ are discussed, and it is suggested that age and, if possible, serological state prior to antigen-exposure should be taken into account when studying isotypic antibody responses after influenza infection or vaccination.
Url:
DOI: 10.1017/S0022172400066316
Affiliations:
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Van Der Logt</name></author><author><name sortKey="Van Beek, Ruud" sort="Van Beek, Ruud" uniqKey="Van Beek R" first="Ruud" last="Van Beek">Ruud Van Beek</name></author><author><name sortKey="Masurel, Nic" sort="Masurel, Nic" uniqKey="Masurel N" first="Nic" last="Masurel">Nic Masurel</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:673723F0193BB8D91CD501776488E2B6E6A74D84</idno><date when="1986" year="1986">1986</date><idno type="doi">10.1017/S0022172400066316</idno><idno type="url">https://api.istex.fr/ark:/67375/6GQ-7CRTPFSL-1/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000095</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000095</idno><idno type="wicri:Area/Istex/Curation">000095</idno><idno type="wicri:Area/Istex/Checkpoint">001062</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001062</idno><idno type="wicri:doubleKey">0022-1724:1986:Beyer W:immunoglobulin:g:a</idno><idno type="wicri:Area/Main/Merge">002486</idno><idno type="wicri:Area/Main/Curation">002370</idno><idno type="wicri:Area/Main/Exploration">002370</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Immunoglobulin G, A and M response to influenza vaccination in different age groups: effects of priming and boosting</title><author><name sortKey="Beyer, Walter E P" sort="Beyer, Walter E P" uniqKey="Beyer W" first="Walter E. P." last="Beyer">Walter E. P. Beyer</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Virology and WHO National Influenza Centre, Erasmus University, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Der Logt, Jos T M" sort="Van Der Logt, Jos T M" uniqKey="Van Der Logt J" first="Jos T. M." last="Van Der Logt">Jos T. M. Van Der Logt</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Microbiology, University of Nijmegen</wicri:regionArea><wicri:noRegion>University of Nijmegen</wicri:noRegion></affiliation></author><author><name sortKey="Van Beek, Ruud" sort="Van Beek, Ruud" uniqKey="Van Beek R" first="Ruud" last="Van Beek">Ruud Van Beek</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Virology and WHO National Influenza Centre, Erasmus University, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Masurel, Nic" sort="Masurel, Nic" uniqKey="Masurel N" first="Nic" last="Masurel">Nic Masurel</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Virology and WHO National Influenza Centre, Erasmus University, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Hygiene</title><title level="j" type="abbrev">J. Hyg.</title><idno type="ISSN">0022-1724</idno><imprint><publisher>Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><date type="published" when="1986-06">1986-06</date><biblScope unit="volume">96</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="513">513</biblScope><biblScope unit="page" to="522">522</biblScope></imprint><idno type="ISSN">0022-1724</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1724</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Fifty volunteers, treated with an inactivated trivalent influenza vaccine containing A/Bangkok/1/79 (H3N2), A/Brazil/11/78 (H1N1) and B/Singapore/222/79 virus, were subdivided according to the estimated first exposure to influenza in their lifetime (priming) and the presence of antibodies against the vaccine components in the pre-vaccination sera. The isotypic antibody response (IgG, IgA, IgM) was determined by means of an antibody capture haemadsorption immunosorbent technique. For all three vaccine components, previously seropositive subjects produced antibodies of the IgG- and IgA-class more frequently than previously seronegative persons. Subjects primed to one of the influenza A subtypes showed more IgG and IgA responses in comparison with those unprimed (prime-effect). In contrast, IgM antibodies occurred in only 19 and 11% of primed, but in 59 and 54% of unprimed subjects, for A (H3N2) and A (HlNl), respectively. The incidence of IgM titre rises was not influenced by the prevaccination state. However, the mean magnitude of anti-A(H1N1)-IgM titre rises was greater in those previously seronegative. The concepts of primary and reinfection and of ‘original antigenic sin’ are discussed, and it is suggested that age and, if possible, serological state prior to antigen-exposure should be taken into account when studying isotypic antibody responses after influenza infection or vaccination.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Hollande-Méridionale</li></region><settlement><li>Rotterdam</li></settlement></list><tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Beyer, Walter E P" sort="Beyer, Walter E P" uniqKey="Beyer W" first="Walter E. P." last="Beyer">Walter E. P. 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